Design and Optimization for Digital Microfluidic Biochips
نویسندگان
چکیده
Microfluidic-based biochips are soon revolutionizing clinical diagnostics and many biochemical laboratory procedures due to their advantages of automation, cost reduction, portability, and efficiency [18]. Conventional technology depends on the manipulation of continuous liquid flow through microfabricated channels. However, actuation of flow is implemented with external assistance of micro-pump and micro-valve, which are complex and cumbersome. Moreover, permanently-etched channels greatly restrict the feasibility and versatility. Regarding this, microfluidic research is witnessing a paradigm shift from the continuous-flow-based architecture to droplet-based architecture or, in particular, the so-called digital microfluidic biochip (DMFB) [1, 4, 5, 11, 14]. Mixing operation Detector
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